1Ashok Kumar BS, 2Disha NS, 3Mohammed Khalid, 4Mamatha, HS
1Department of Pharmacognosy, RL Jalappa College of Pharmacy, Jalappa College of Pharmacy, Sri Devaraj Urs Academy of Higher Education and Research ( A Deemed to be University), Tamaka, Kolar, Karnataka, India.
2Department of Pharmaceutical Chemistry, RL Jalappa College of Pharmacy, Jalappa College of Pharmacy, Sri Devaraj Urs Academy of Higher Education and Research ( A Deemed to be University), Tamaka, Kolar, Karnataka, India
3,4Department of Pharmaceutics, RL Jalappa College of Pharmacy, Jalappa College of Pharmacy, Sri Devaraj Urs Academy of Higher Education and Research ( A Deemed to be University), Tamaka, Kolar, Karnataka, India
DOI : https://doi.org/10.47191/ijmra/v7-i12-33Google Scholar Download Pdf
ABSTRACT:
Reye syndrome is a rare, acute, and potentially life-threatening condition marked by rapid liver and brain damage, primarily affecting children and adolescents following viral infections like influenza or varicella. Though the exact cause remains unclear, studies indicate a strong association with the use of aspirin and other salicylates during viral infections, which may disrupt mitochondrial function and lead to hepatic steatosis and encephalopathy. Given the risks of aspirin use in susceptible populations, exploring natural anti-inflammatory alternatives is essential. Turmeric (Curcuma longa), ginger (Zingiber officinale), Boswellia serrata, Pinus pinaster, and Paeonia lactiflora possess notable anti-inflammatory, hepatoprotective, and neuroprotective properties, potentially mitigating inflammation without salicylate risks. Curcumin in turmeric and gingerol in ginger exhibit antioxidant and anti-inflammatory effects by modulating inflammatory pathways. Boswellia’s boswellic acids, Pinus pinaster’s proanthocyanidins, and Paeonia lactiflora, paeoniflorin further contribute to immune modulation and neuroprotection. This review discusses these natural alternatives' mechanisms and their potential role in preventing and managing inflammation in children at risk of Reye syndrome, highlighting the need for further studies to validate their safety and efficacy in pediatric populations.
KEYWORDS:Reye syndrome, viral infection, Aspirin, Natural Anti-inflammatory
REFERENCES1) Ammon, H. P. (2016). Boswellic acids and their role in chronic inflammatory diseases. Anti-inflammatory Nutraceuticals and Chronic Diseases, 291-327.
2) Azeez, T. B., & Lunghar, J. (2021). Anti-inflammatory effects of turmeric (Curcuma longa) and ginger (Zingiber officinale). Inflammation and Natural Products, 83-102.
3) Belcaro, G. V. (2016). Pharma-standard Supplements: Clinical Use. World Scientific.
4) Biagi, M., Rigillo, G., Sarill, M., Collotta, D., Di Giacomo, S., Di Sotto, A., Grilli, M., Luceri, C., Milella, L., Sangiovanni, E., & Vitalone, A. (2023). From preclinical to clinical evidence: Exploring the multiple perspectives and healing power of Boswellia serrata Roxb. ex Colebr. PHARMADVANCES, 5(1), 29-53.
5) Chillemi, S., & Chillemi, M. (2013). Natural Remedies for Common Conditions: How to Prevent, Heal and Maintain Optimum Health Using Alternative Medicine, Herbals, Vitamins and Food. Lulu.com.
6) Dey, R., Dey, S., Samadder, A., Saxena, A. K., & Nandi, S. (2022). Natural inhibitors against potential targets of cyclooxygenase, lipoxygenase, and leukotrienes. Combinatorial Chemistry & High Throughput Screening, 25(14), 2341-2357.
7) Ferreira-Santos, P., Zanuso, E., Genisheva, Z., Rocha, C. M., & Teixeira, J. A. (2020). Green and sustainable valorization of bioactive phenolic compounds from Pinus by-products. Molecules, 25(12), 2931.
8) Gurib-Fakim, A. (2006). Medicinal plants: Traditions of yesterday and drugs of tomorrow. Molecular Aspects of Medicine, 27(1), 1-93.
9) Islam, M. R., Rauf, A., Akash, S., Trisha, S. I., Nasim, A. H., Akter, M., Dhar, P. S., Ogaly, H. A., Hemeg, H. A., Wilairatana, P., & Thiruvengadam, M. (2024). Targeted therapies of curcumin focus on its therapeutic benefits in cancers and human health: Molecular signaling pathway-based approaches and future perspectives. Biomedicine & Pharmacotherapy, 170, 116034.
10) Lim, T. K. (2014). Paeonia lactiflora. In Edible Medicinal and Non-Medicinal Plants: Volume 8, Flowers (pp. 559-596). Dordrecht: Springer Netherlands.
11) Lopez, G. A. (2019). Femicide and gender violence in Mexico: Elements for a systemic approach. The Age of Human Rights Journal, (12), 158-183. https://doi.org/10.17561/tahrj.n12.9
12) Ma, X., Wen, J. X., Gao, S. J., He, X., Li, P. Y., Yang, Y. X., Wei, S. Z., Zhao, Y. L., & Xiao, X. H. (2018). Paeonia lactiflora Pall. Regulates the NF-κB-NLRP3 inflammasome pathway to alleviate cholestasis in rats. Journal of Pharmacy and Pharmacology, 70(12), 1675-1687.
13) Mashhadi, N. S., Ghiasvand, R., Askari, G., Hariri, M., Darvishi, L., & Mofid, M. R. (2013). Anti-oxidative and anti-inflammatory effects of ginger in health and physical activity: Review of current evidence. International Journal of Preventive Medicine, 4(Suppl 1), S36.
14) Micozzi, M. S. (2018). Western herbalism and ethnobotany. In Fundamentals of Complementary, Alternative, and Integrative Medicine-E-Book (pp. 374).
15) Moreillon, J. J. (2010). Effects of eight weeks of curcumin and Boswellia serrata supplementation on plasma markers of inflammation and antioxidant activity in chronic kidney disease patients. Baylor University.
16) Rohdewald, P. J. (2005). Pycnogenol®: French maritime pine bark extract. In Encyclopedia of Dietary Supplements (pp. 545-553).
17) Shao, G., Liu, Y., Lu, L., Zhang, G., Zhou, W., Wu, T., Wang, L., Xu, H., & Ji, G. (2022). The pathogenesis of HCC driven by NASH and the preventive and therapeutic effects of natural products. Frontiers in Pharmacology, 13, 944088.
18) Siddiqui, M. Z. (2011). Boswellia serrata, a potential anti-inflammatory agent: An overview. Indian Journal of Pharmaceutical Sciences, 73(3), 255.
19) Weichmann, F., & Rohdewald, P. (2024). Pycnogenol® French maritime pine bark extract in randomized, double-blind, placebo-controlled human clinical studies. Frontiers in Nutrition, 11, 1389374.
20) Xin, Q., Yuan, R., Shi, W., Zhu, Z., Wang, Y., & Cong, W. (2019). A review for the anti-inflammatory effects of paeoniflorin in inflammatory disorders. Life Sciences, 237, 116925.
Volume 07 Issue 12 December 2024
There is an Open Access article, distributed under the term of the Creative Commons Attribution – Non Commercial 4.0 International (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/), which permits remixing, adapting and building upon the work for non-commercial use, provided the original work is properly cited.
Our Services and Policies
Authors should prepare their manuscripts according to the instructions given in the authors' guidelines. Manuscripts which do not conform to the format and style of the Journal may be returned to the authors for revision or rejected.
The Journal reserves the right to make any further formal changes and language corrections necessary in a manuscript accepted for publication so that it conforms to the formatting requirements of the Journal.
International Journal of Multidisciplinary Research and Analysis will publish 12 monthly online issues per year,IJMRA publishes articles as soon as the final copy-edited version is approved. IJMRA publishes articles and review papers of all subjects area.
Open access is a mechanism by which research outputs are distributed online, Hybrid open access journals, contain a mixture of open access articles and closed access articles.
International Journal of Multidisciplinary Research and Analysis initiate a call for research paper for Volume 07 Issue 12 (December 2024).
PUBLICATION DATES:
1) Last Date of Submission : 26 December 2024 .
2) Article published within a week.
3) Submit Article : editor@ijmra.in or Online
Why with us
1 : IJMRA only accepts original and high quality research and technical papers.
2 : Paper will publish immediately in current issue after registration.
3 : Authors can download their full papers at any time with digital certificate.
The Editors reserve the right to reject papers without sending them out for review.
Authors should prepare their manuscripts according to the instructions given in the authors' guidelines. Manuscripts which do not conform to the format and style of the Journal may be returned to the authors for revision or rejected. The Journal reserves the right to make any further formal changes and language corrections necessary in a manuscript accepted for publication so that it conforms to the formatting requirements of the Journal.